The new clip shows gameplay footage from the upcoming first-person shooter, including new shots from the skies of Columbia.
It also offers glimpses at how the Sky-Hook can be used in the game, along with how Elizabeth can be an ally in combat situations.
The Irrational Games project takes place in 1912, and follows the previous BioShock series which took place underwater in Rapture.
BioShock Infinite is scheduled to release for PC, Xbox 360 and PlayStation 3 on February 26, 2013.
Two limited editions of the game will also be released on all three platforms.
Watch a 15 minute gameplay video for BioShock Infinite below: