Bethesda's stealth-based action game once again charts above XCOM: Enemy Unknown in second and Guild Wars 2, which climbs to third.
Elsewhere, Rocksmith makes its debut at five having finally released on the PC, above Doom 3: BFG Edition, which goes straight in at six.
The top ten in full:
1. (1) Dishonored (Bethesda)
2. (2) XCOM: Enemy Unknown (2K Games)
3. (4) Guild Wars 2 (NCSoft)
4. (3) Mists of Pandaria (Activision Blizzard)
5. (-) Rocksmith (Ubisoft)
6. (-) Doom 3: BFG Edition (Bethesda)
7. (6) The Sims 3: Supernatural (Electronic Arts)
8. (5) The Sims 3 (Electronic Arts)
9. (7) Borderlands 2 (2K Games)
10. (8) The Elder Scrolls V: Skyrim (Bethesda Softworks)
Leisure software charts compiled by Chart Track, (C) 2012 UKIE Ltd.
Watch a trailer for Dishonored below: