Described by Edmund McMillen as the "strangest project I've ever worked on", the platform title will involve randomly generated elements and mutant cats.
Little else is known about the title, including release dates and platforms, although the project is said to be moving fast, with more details coming soon.
The game will be released before the iOS version of Super Meat Boy, which is currently on hold.
Super Meat Boy for PC and Xbox 360 hit the sales milestone of 1 million units in January.
> Read Digital Spy's review of Super Meat Boy
Watch a trailer for Super Meat Boy below: