Described as an "innovative reinvention of Populous", GODUS enables users to build cults and battle other gods in multiplayer.
The gameplay will be instantly accessible, but "immensely deep" with a game world that changes based on a player's actions.
"Populous was created over 22 years ago, and we believe that to date, nothing has come close to emulating its powerfully godlike experience. It's this experience we aim to reimagine," reads Molyneux's Kickstarter pitch.
"GODUS blends the power, growth and scope of Populous with the detailed construction and multiplayer excitement of Dungeon Keeper and the intuitive interface and technical innovation of Black & White.
"The original Populous hailed from the 8-bit era but GODUS will use the most modern technology the world has to offer."
Peter Molyneux and his team at 22 Cans have turned to Kickstarter in an attempt to raise the £450,000 needed to make the game a reality.
If successful, GODUS will be available on the PC and mobiles within a year.
GODUS follows recent 22 Cans release Curiosity: What's Inside the Cube, which sees every player chipping away at the same virtual cube in an attempt to discover what's inside.
However, only the player who performs the final tap will be able to view its contents.
The experiment will reveal whether the final player unearths the cube's contents and how they do so.
22 Cans will monitor how news of the cube's contents spreads on social media, and use the findings in a future release. 30 layers have so far been removed, with more than 90 million individual cubes still to go.
Originally scheduled for August, it was renamed due to a clash with the Mars rover Curiosity.
Watch the GODUS Kickstarter video below: