Based at Staybridge Suites London Stratford City, the GAME Pad suite features gaming zones dedicated to PlayStation 3, Xbox 360 and Wii U.
Guests will have the opportunity to play the latest releases on each console and help themselves to pizza, snacks, beer, wine and soft drinks from a fully-stocked fridge.
"We know that this time of year, gamers yearn to escape from all things Christmassy to indulge in their passion," said GAME marketing director Anna-Marie Mason.
"With loads of amazing launches in the last few months, games are top Christmas presents this year but so many gamers won't have enough time to enjoy and play them in peace, be this due to demanding jobs, children to look after or housemates who won't let them hog the TV.
"We want to make it easy for gamers this Christmas by offering them a brilliant gaming getaway which allows them the luxury of uninterrupted gaming."
The GAME Pad, which also includes a non-gaming television and king-sized bed, is available to book now for an overnight stay in January, priced at £199.