Capcom has announced that it will distribute the fan-made game this month to mark the 25th anniversary of both properties.
Created and developed by Singaporean programmer Seow Zong Hui, the game is rendered in the same graphical style as the 8-bit Mega Man titles and sees the protagonist tackle Street Fighter-themed levels.
Street Fighter's roster of characters will serve as end-of-level bosses and will use their signature special moves against Mega Man.
"Our fans have been so supportive of the 25th Anniversary efforts on Street Fighter, that we wanted to provide one last surprise and token of our appreciation," said Christian Svensson, SVP of Capcom USA.
"This game symbolises the passion and dedication of our fans and with the 25th Anniversary of Mega Man coming up, we felt it was our duty to bring this wonderful experience to everyone who has shared the last 25 years with us and both of these celebrated franchises."
Street Fighter X Mega Man will be available to download for PC on December 17.