Narrated by squad leader Dalton Brooks, the latest Fuse video offers a glimpse at a typical mission involving the Overstrike agents.
The trailer looks at the game's four playable characters, as well as a number of its environments and enemies.
Formerly known as Overstrike, Fuse was officially unveiled and detailed at PAX in Seattle earlier this year.
The co-operative shooter centres around Fuse, a volatile energy source that each of the four players can use for different weapons.
Dalton, for example, uses a Mag-shield that can provide portable cover, while Izzy Sinclair, the team's tech specialist, uses the shattergun which can freeze enemies in crystal and heal allies.
Fuse will be Insomniac's first multiplatform game, releasing on the Xbox 360 and PS3 with a number of pre-order incentives in early 2013.
Watch another trailer for Fuse below: