The games affected include James Bond 007: Blood Stone, Quantum of Solace and the recently released 007 Legends, which are no longer available on Activision's online store or through Steam.
The same games, along with GoldenEye Reloaded, are also no longer available to download through Xbox Live or PlayStation Network.
The only exception appears to be Blood Stone, which is still available on PC if downloaded through Games for Windows Live even though it is missing from all other stores.
Activision has not commented on what caused the games to be removed.
It is likely that the games were pulled due to an issue with the James Bond license, though Activision's deal with MGM and EON to distribute games based on the series is not supposed to expire until 2014.
The latest game in the series, 007 Legends was poorly received by critics when it launched in October last year. Activision then shut down Eurocom, the studio that had developed the game, in December.
It is possible that the game's poor performance prompted Activision to end its license for the franchise early, though there are any number of other issues that could have also caused the games to be pulled.
Last year Grand Theft Auto: Vice City was removed from stores just as suddenly due to a licensing dispute over a song in the game, and returned within a month.
> Read Digital Spy's review of '007 Legends'
Watch the trailer for 007 Legends below: