The action game will launch on Xbox Live Arcade from February 20 for 800 Microsoft Points (£6.80 / $10).
The XBLA release is an enhanced version of 2011's Serious Sam Double D on PC, adding local co-operative multiplayer and expanded levels with new rooms and enemies.
It also adds weapon customisation, with four unlockable alternate abilities for each weapon including swarms of bees and the series' signature cannon.
Developed by Mommy's Best Games, Serious Sam Double D XXL is a 2D side-scrolling spin-off of the over-the-top shooter series. Its key feature is the gunstacker, letting players customise a stack of up to six guns and fire them at once.
Serious Sam Double D XXL is releasing exclusively on Xbox Live Arcade next month.