The clip combines gameplay from the upcoming 3DS title with live-action footage of a boy attempting to rid his home of ghosts.
The follow-up to the Gamecube launch title will feature multiple mansions for Luigi to explore, filled with ghosts to capture and puzzles that will unlock new rooms.
Luigi will use a vacuum called the Poltergust 3000 to capture ghosts and can use wind to interact with the environment for puzzle solving.
The game will also take advantage of the 3DS's gyroscope, which can be used to aim Luigi's flashlight and vacuum, and feature a local multiplayer mode.
Luigi's Mansion: Dark Moon will be released on March 28 in Europe.
Gallery: View the latest images for Luigi's Mansion: Dark Moon: