Series creator Dan House revealed that the game has never been adapted for cinema because the money on offer has never been worth the risk and the level of creative freedom would be restricted.
"We've been offered, many times, and it's never appealed. The money's never been close to be worth risking one's crown jewels," he told The Guardian.
"Our small dabblings with Hollywood have always left us running back to games. The freedom we have to do what we want creatively is of enormous value. The second you go near Hollywood, people seem willing, or have been forced, to lose a lot of that control.
"That sort of amorphous 'that won't test well' attitude is exactly how we don't work. We've always tried to think of stuff that's innovative and new, and to go into a world where that's not encouraged would be horrible."
The latest entry is the bestselling crime series, GTA 5, will be released for Xbox 360 and PlayStation 3 on September 17.
> GTA 5 timeline: From announcement to release, every trailer so far
Watch a trailer for GTA 5 below: