Gaming
The acclaimed release, which also won best Xbox 360 Game and Best Score, added the trophy to a host of awards previously won including Best Game at this year's BAFTA Video Game Awards.
The awards, which were hosted by Samuel L Jackson, saw Call of Duty 4: Modern Warfare, Super Mario Galaxy and Halo 3 all collect two gongs each.
Other notable winners included Mass Effect, which won best RPG, and The Orange Box, which won best PC game.
The full list of winners is:
Game of the Year: BioShock
Best Shooter: Call of Duty 4: Modern Warfare
Best Action Game: Super Mario Galaxy
Best Rhythm Game: Rock Band
Best RPG: Mass Effect
Best Driving Game: DiRT: Colin McRae
Best Military Game: Call of Duty 4: Modern Warfare
Studio of the Year: Harmonix
Best Graphics: Crysis
Breakthrough Technology: The Orange Box/Portal
Best PS3 Game: Ratchet and Clank Future: Tools of Destruction
Best Wii Game: Super Mario Galaxy
Best Xbox 360 Game: BioShock
Best PC Game: The Orange Box
Best Individual Sports Game: Skate
Best Team Sports Game: Madden NFL 08
Best Handheld Game: The Legend of Zelda: Phantom Hourglass
Best Game Based on a Movie or TV Show: The Simpsons Game
Best Soundtrack: Rock Band
Best Original Score: BioShock
Best Multiplayer Game: Halo 3
Most Addictive Game: Halo 3
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