The former heavyweight champion boxer will be available as a playable character as a pre-order bonus for the wrestling title.
Tyson made several appearances in WWE during the sport's 'Attitude Era', notably as a ringside enforcer between Shawn Michaels and Steve Austin in 1998.
He later appeared as a guest host on Monday Night Raw in 2010, and was inducted into the WWE Hall of Fame last month.
In the game, Tyson will sport the same DX t-shirt and black jeans from his ringside appearance.
Copyright: THQ"As one of the most dominant champions in boxing history and one of the most memorable guests to ever be featured on WWE programming, Mike Tyson led an incredible revolution that changed the way fans perceive the sport," said vice president of global brand management Sean Ratcliffe.
"He was a tremendous addition to the 'Attitude Era' and is certain to attract a wide variety of fans to 'live the revolution' offered in WWE 13."
Announced earlier this year, WWE 13 will feature a roster of 77 Superstars, context sensitive 'OMG' moments and an 'Attitude Era' single-player story mode.
It will be available on Xbox 360, PS3, PC and Wii from October 30 in North America and November for Europe.
View the announcement trailer for WWE 13 below: