Titled Men's Hour, the six-part series will be "less about leering at ladies and more concerned with how to maintain monogamy".
Presented by journalist Tim Samuels, Men's Hour will "delve into unchartered emotional territory for men", including topics such as relationships and health.
Each week, the programme will welcome a range of guests from the worlds of sport, entertainment and politics for regular features, such as Questions You Daren't Ask Your Doctor and Midlife Music Crisis.
Choreographer and Pineapple Dance Studios star Louie Spence will also join Samuels as a regular weekly guest. The hour-long show will make its debut on July 18 at 7.30pm.
"It's about capturing the spirit of when good mates sit around nowadays - amid all the banter you can actually open up about what's on your mind without being ripped apart," said Samuels.
"We're celebrating modern man's mix of swagger and neurosis."
Men's Hour With Tim Samuels will be produced by BBC 6 Music presenter Jon Holmes for Tonic Productions, in association with Fresh One Productions.
Radio 4's Woman's Hour, which is currently presented by Jenni Murray, has been on the air since 1946 with a range of features aimed at women. In January 2005, the programme became Man's Hour for a day, presented by Channel 4 News host Jon Snow.
In further changes to the Radio 5 Live schedule, Holmes will present a one-off programme, titled Jon Holmes' Mob Rule, on July 25 from 6.30pm.
The programme will see Holmes and special guests discussing public views on a variety of local and global issues expressed via Twitter, phone-ins, blogs and other outlets.
Richard Bacon will also host a new seven-part Sunday morning topical series, titled Chart The Week, from July 18 at 11am. The show will involve Bacon and some special guests discussing the ten most talked about stories from the preceding week.