In a statement, the corporation said that moving the morning programme to the new BBC North headquarters in Greater Manchester is intended to "build on the show's current success and enhance its strong reputation for providing news and features from across the UK".
After the move, Breakfast will benefit from an "iconic waterside location" offering views of The Lowry Theatre, the Imperial War Museum North and the Manchester Ship Canal.
However, some BBC Breakfast staff are reportedly very "upset" over the planned move from London to Manchester, which one source described as "utter madness".
BBC News director Helen Boaden, who allegedly broke the news to staff yesterday, said: "BBC Breakfast is the most watched breakfast programme in the UK and loved by millions.
"It has a fantastic connection with audiences across the UK and we want to build on that. Clearly this involves personal and professional decisions for the talented team who make Breakfast but we will be supporting them to reach an informed judgement about the move."
Around 2,300 BBC staff positions are due to make the move from London to the new Salford base, including the corporation's sport, children's, learning and future media and technology departments, along with parts of Five Live.
As part of the move, 88 roles across BBC Breakfast will be relocated to BBC North, but the programme will remain part of BBC News and accountable to Boaden.
Over three hours per day of live BBC One output will eventually come from Salford to demonstrate the BBC's commitment to production outside of London.
BBC North director Peter Salmon said: "The move of Breakfast is especially symbolic as it is the first time a BBC Network News programme will come from outside London - a real vote of confidence in our new enterprise.
"Today's announcement shows just how serious we are about creating a world-class media hub in the North of England by better reflecting and serving all our viewers and listeners - wherever they live."