Starring Brenda Gilhooly as Gayle, the 60-minute pilot is being filmed in a documentary style by production company Black Orchid.
The programme, which will air on Living in September, follows Gayle's progress as she attempts to revive her career in showbusiness, including botox treatment, charity work and a reality cookery show.
The script has been written by Harry Hill, who will also appear in the pilot, along with chef Heston Blumenthal and Pineapple Dance Studios star Louie Spence.
Other cameos in the programme will come from Ainsley Harriott, Toyah Willcox, Paul O'Grady and Hollyoaks actress Roxanne McKee.
"Gayle is back, and where else would she want to be than on Living, the UK's top celebrity channel," said the Living TV Group's head of commissioning Mark Sammon.
"We know that Living's young audience love scripted comedy on the channel, like US hit Cougar Town, so we're very excited to have made our first commissioning step into this genre and to have secured the services of such a great comedy writer and performer in Brenda."
Black Orchid Productions' producer Pete Ward added: "Gayle Tuesday is a unique character who is unashamedly enthusiastic about the world of celebrity. It is the first scripted comedy for Living, and we are delighted to be at the forefront of that."
Gilhooly's Gayle Tuesday character first appeared on television in Channel 4's Viva Cabaret, but later secured her own show, Gayle's World.