Over the past eight months, Brighton-based web design agency Clearleft has been working with Channel 4 News to ensure the new site "exudes the core values of the programme".
The redesigned site sees the online news team focus on more extensively covering its core area stories rather than attempting to cover every single short-form news story of the day.
Building on the success of live-blogging events such as Channel 4's Ask the Chancellors and the general election debates, the 7pm daily bulletin will now be live-blogged every evening.
The new site will also bring together Twitter feeds from presenters Jon Snow and Krishnan Guru Murthy, as well as specialist editors including Lindsey Hilsum, Faisal Islam and Gary Gibbon.
The site launches with a new blog from Guru Murthy, titled GuruBlog, which will cover the news issues of the day, along with music, technology and other areas.
To mark the launch, Channel 4 News is searching for the UK's 'Best Young Blogger' in a contest judged by Jon Snow, broadcaster Richard Bacon, political commentator Iain Dale and Guardian journalist Josh Halliday. The winner's work will be posted on the Channel 4 News site alongside the more famous bloggers.
Another new feature on the site is Special Reports, featuring in-depth reporting and analysis from across the Channel 4 News team.
The site has further undergone technical enhancements, including a "far greater focus" on information graphics, starting with a map scaling the sexual abuse convictions within the Catholic Church in England and Wales.
Using the BrightCove5 video playback system, the site will bring video content to iPad, iPhone and Android 2.2. However, users are still unable to access a live stream of the 7pm bulletin.
"We know that our viewers strongly identify with some of the core values of our programme - they see Channel 4 News as challenging, distinctive and, at times, a little bit mischievous. What we wanted to do was ensure that these defining characteristics also shape our online output," said Vicky Taylor, Channel 4's commissioning editor for new media, news and current affairs.
"The new site celebrates our wealth of in-depth coverage in specialist areas ranging from Iran to G20 - and offers the same real-time commentary that people are currently accessing through our social media activity."
Channel 4 News Online senior editor Ed Fraser added: "We want to create a real time conversation and buzz around the Channel 4 News programme.
"We saw quite clearly that people enjoyed the community feel of commenting on and discussing news events as they unfolded during the general election - and that, for these, people live-blogging was enhancing the viewing experience. It was so successful that now we will be providing the forum for live discussion every night."
Alongside the new sections, many of the site's most popular features remain available, including political correspondent Cathy Newman's FactCheck blog, the WhoKnowsWho map of links between people in the public eye and Jon Snow's early evening Snowmail.