From April 4, Radcliffe and Maconie will host the weekday 1pm to 4pm slot on 6 Music, presenting a show that will "reflect the rich relationship that the station has with Manchester and music from the North of England".
The Radcliffe And Maconie Show will feature 6 Music's "heritage" artists, such as Massive Attack, The Smiths, David Bowie, and Blur, along with new talent like The Vaccines and Field Music. Nemone, who currently presents the afternoon slot, will move to weekend breakfast from April 9.
Radcliffe and Maconie will both retain a presence on Radio 2 - Radcliffe hosting a new late-night slot every Tuesday from 11pm to midnight, and Maconie fronting a new series on the history of pop music, scheduled to broadcast in 2012.
"Moving to 6 Music is a wonderful opportunity for Stuart and I to be part of the digital radio revolution and also the establishment of MediaCityUK in Salford," said Radcliffe.
"We feel like we have signed up to the future in a big way. The music policy of 6 is right up our street with its blend of heritage tracks and emerging new talent."
Maconie added: "6 Music provides a priceless service to its legions of fans, and I'm happy to be joining the merry bandwagon of joy. The usual inane banter will remain, the only difference will be the hour - let there be light!"
The Radcliffe And Maconie Show will be replaced on Radio 2 by a new programme hosted by Jo Whiley, who leaves Radio 1 after 17 years. Her programme will provide a "trusted guide" to popular music for Radio 2 listeners, including well known bands and new artists.
Discussing her departure from Radio 1, Whiley said: "I've loved working at Radio 1 for the past 17 years. It's given me opportunities I could only have dreamt of - Coldplay's first Live Lounge, Arctic Monkeys covering Girls Aloud's 'Love Machine', Jay Z performing live in my own lounge - I've even measured the distance between Bono's nipples live on air...don't ask.
"As well as supporting my love of music, Radio 1 have also supported and accommodated me bringing three further children into the world - something, as a woman, I will always be grateful for."