The broadcaster's coverage of the Chilean miners rescue is shortlisted, while Dispatches investigation, Politicians For Hire, is up for 'Scoop of the Year'. Jon Snow, the Channel 4 News anchor, is in the running for 'Presenter of the Year'.
Speaking to Journalism.co.uk, Channel 4 head of news and current affairs Dorothy Byrne said: "It's hugely gratifying for our news and current affairs coverage to be recognised with an unprecedented number of nominations.
"The range and depth of our original reporting is reflected in these nominations - we're delighted to have picked up two of the three in the international reporting category, as well as 'Scoop of The Year' for Politicians for Hire."
ITN, which produces news content for Channel 4 and ITV News, is up for 19 categories in total, while the BBC and ITV have 11 nominations each.
The BBC News Channel, Sky News and al-Jazeera English will all compete for the prestigious 'News Channel of the Year' award. ITV News, Five News and Channel 4 News are up for 'News Programme of the Year'.
Sky News has eight nominations in total, including Alex Crawford up for 'Television Journalist of the Year' for the second year running.
Mark Kleinman, the Sky News business editor, is shortlisted in the specialist journalist category, but he will face competition from ITV News political editor Tom Bradby and the Channel 4 News political editor, Gary Gibbon.
The World Cup Twitter buzz visualisation created by US broadcaster CNN is up for the news innovation award, alongside ITV's Instant Polling service during last year's general election and the BBC News' Live page.
The awards will be presented at a ceremony hosted by Channel 4 News presenter Krishnan Guru-Murthy on February 23 at the London Hilton on Park Lane.