Littleford, UKTV's controller, yesterday announced his intention to step down from the broadcaster, although no leaving date or successor has yet been confirmed.
He joined UKTV in 2007 and went on to oversee a major overhaul of the company's portfolio of channels, including the launches of Dave, Really and Good Food.
"After nearly four years at UKTV, I've decided that it's time for me to take on a new creative challenge," said Littleford.
"During my time at UKTV, the network undertook the most ambitious rebrand in broadcasting history - nine channels and a brand new channel Watch. Last year was a great year - our channels are going great guns and we've won loads of awards."
Darren Childs, who became UKTV's new chief executive last August, added: "I've enjoyed working with Matthew. He's a talented and creative exec who has helped establish UKTV as one of the UK's leading broadcasters.
"Thanks to his work and dedication, UKTV is well placed to tackle the next stage of its creative evolution and I wish him well in his next endeavour."
Littleford's departure comes after UKTV confirmed plans to appeal a court ruling that could force Dave to rebrand as part of a trademark wrangle with a brand consultancy of the same name.