More than 100 school children from across the North West and Yorkshire will attend the new BBC North production studios at the MediaCityUK complex to produce the live bulletin.
The BBC News School Report works with schools across the UK to help pupils aged 11 to 14 to make their own news reports and broadcast them to real audiences.
Tomorrow's report will see the school children investigating various issues, including the government spending cuts and new technology developments.
The report will be broadcast live from Salford Quays at 2pm on the BBC Red Button and online, marking the first ever live TV broadcast from the BBC North site. Parts of the report will also later be aired on other BBC programmes.
Due to the landmark nature of the occasion, Radio 5 Live, Radio Manchester, North West Tonight and Newsround will all report from MediaCityUK tomorrow.
Helen Boaden, director of BBC News, said: "It will be a very exciting moment at 2pm on March 24 when BBC School Report broadcasts the first live television from the amazing new studios at MediaCityUK.
"It is wonderful that local children from Salford and across the North West and Yorkshire will be the ones producing the news reports that will make history on Thursday."
The new BBC studios, operated by MediaCityUK owner Peel Media and technology firm SIS, have already hosted recordings of A Question of Sport and Don't Scare The Hare, a new light entertainment show made by Endemol for BBC One.
Last Friday, BBC Radio 4's Woman's Hour became the first live radio broadcast from MediaCityUK when presenter Jenni Murray presented a Comic Relief special edition of the programme from the new radio studios.