During the three-day festival in Manchester, due to be hosted by BBC 6 Music duo Mark Radcliffe and Stuart Maconie, Brittin will give a speech covering the latest developments at Google and the role of the internet in driving economic growth.
Outside of the US, Britain is the largest market for search engine giant Google. Brittin joined the company in 2007 and is also currently a non-executive director at Sainsbury's and a board trustee of the Media Trust.
"Radio is powerful, intimate, emotionally engaging and highly creative, and it still plays a huge part in today's media landscape," he said.
"The internet has allowed developments such as 'listen again' and provides opportunities for increasing interactivity with listeners.
"The Radio Festival is a great opportunity to debate future developments and ways in which businesses can reach their full potential. I am delighted to be attending."
John Myers, the chief executive of The Radio Academy, said: "Google is one of the world's biggest businesses. It is really exciting to have Matt confirmed as a keynote speaker.
"The way radio uses the internet is critical to its future and who better to set the landscape than the UK boss of the world's biggest internet company."
Brittin joins Mark Thompson as a keynote speaker for this year's festival, with the BBC director general to discuss the impact of the new BBC licence fee settlement hastily agreed last year.
Thompson is currently leading the BBC's Delivering Quality First initiative aimed at finding ways to accommodate sweeping cuts of up to 20% across the corporation's budget.
BBC legend 'Whispering' Bob Harris will also deliver a talk at the festival, along with Dragons' Den star Duncan Bannatyne. The 2011 Radio Festival will run from October 31 to November 2 at The Lowry arts and entertainment centre in Salford.