The Health Lottery, officially unveiled in February, is being run by Desmond's Northern & Shell group, owner of Express Newspapers and OK! magazine.
Consumers will be able to purchase tickets for £1 with the possibility of winning a £100,000 top prize for matching five numbers.
The draw will be shown in adverts on Saturday evenings on ITV1 and Channel 5. Four matching numbers will win players £500, while three will collect £50.
The Health Lottery will donate 20p from each £1 ticket purchased, which is not as generous as the 28p from every National Lottery ticket.
Sir Stephen Bubb, of the Association of chief executives of Voluntary Organisations, told BBC News that the level of donation was a "pretty disgraceful development".
However, Health Lottery chief executive Martin Hall said that the game would benefit communities in the UK, and ultimately pay out a greater proportion of income in prizes than the National Lottery does.
Desmond has reportedly signed up more 40,000 retailers to sell tickets for the Health Lottery, 12,000 more than the National Lottery.
Tickets will go on sale on Thursday, backed by a £20m publicity campaign.
The billionaire has said that the lottery will earn around £50m a year for health-related causes, potentially including young carers, the fight again Alzheimer's disease and specialist nurses.
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