The portion of today's show has been widely criticised in online blogs and on Twitter, but Wright has stood by the decision to run it.
A description on the Channel 5 website read: "So Amanda Knox has been cleared of the murder of British student Meredith Kercher. She's entirely innocent.
"She's also undeniably fit and loves wild sex. Or did. So if you were a guy who'd met her in a bar and she invited you back to hers, would you go? I'm being quite serious. Or would something in your brain make you think twice?"
Following criticism, Wright told Metro: "For the last four years, the world has been more than happy to refer to a woman, then presumed to be a killer, as 'Foxy Knoxy', something I find appalling.
"I thought it would be interesting to find out if mud sticks, or whether an innocent young woman could now go out and behave in a perfectly normal way. The real disgrace is the Foxy Knoxy epithet."
A spokesperson for the show added: "The discussion conducted between Matthew Wright and our panel of Kelly Hoppen, Christopher Biggins and Liz McClarnon was handled extremely sensitively.
"At no point did we lose sight of the fact that at the heart of the matter is the tragic death of a young girl - Meredith Kercher."
> Daily Mail launches inquiry into 'guilty' Amanda Knox gaffe