The BBC has announced that the David Dimbleby-fronted debate show will air from Westminster for the first time in its 32-year history.
Question Time's editor, Nicolai Gentchev, told The Guardian: "I hope this magnificent venue inspires the debate among our panel and audience."
The move coincides with 'Parliament Week' in the UK and comes during the production team's much-criticised move from London to Glasgow.
Earlier this year, the programme achieved a similar landmark after airing from Wormwood Scrubs prison.
Question Time returned for a new series earlier this year, following a London riots special in August.