The newspaper's fifth annual list places London Mayor Boris Johnson as the most influential person, ahead of prime minister David Cameron. The pair shared the top spot last year.
Prince William and Kate Middleton have been named as the most influential royals in the list after the new Duke and Duchess of Cambridge opted for a home in the capital.
Kate's sister Pippa Middleton has joined the top 20 for the first time, alongside royal wedding dress designer Sarah Burton and Westfield shopping centre boss Michael Gutman.
Also named in the list was Tottenham-born singer Adele, who has had a meteoric rise to global fame with her multi-million selling new album 21.
After Johnson and Cameron, Chancellor George Osborne and Bank of England Governor Sir Mervyn King were third and fourth in the list, while deputy prime minister Nick Clegg placed fifth.
There were also places in the top 20 for London mayoral candidate Ken Livingstone, RMT Tube union leader Bob Crow and new Metropolitan Police commissioner Bernard Hogan-Howe.
Among the high profile names to drop out of the top 20 most influential Londoners was embattled News Corporation executive James Murdoch, who will testify again in front of MPs on Thursday over the phone hacking scandal.
Simon Cowell has also dropped down the pecking order after ratings for ITV's The X Factor slumped following his decision to prioritise the US version of the show.
London Evening Standard editor Geordie Greig said: "Our capital leads the way in so many arenas from sport, finance, film, publishing and medicine to fashion and design. The London Evening Standard is proud to celebrate those who make our city great."
The full list of the top 1,000 most influential Londoners will be published tomorrow (November 9) in print, online and on iPad by the London Evening Standard.
Watch the video for Adele's 'Someone Like You' below: