The mother-of-two completed her final 6am to 8am breakfast show on the station at the weekend after two and a half years in the early slot.
The former Radio 1 breakfast presenter informed listeners at the weekend that she wanted to spend more time with her children, Woody, 11, and Nelly, 2, along with DJ husband Norman Cook.
"You have been such splendid company, but after three glorious years of early rising my other family - my three monkeys at home - have decided they'd quite like me to themselves at weekends," she said.
Ball has been doing the show since June 2009, although she had a break in January 2010 when she gave birth to her second child.
She will remain on the books at Radio 2 as a cover presenter, including regular cover for Ken Bruce's weekday mid-morning show on the station.
"I look forward to continuing as Ken Bruce's stunt double when he's on holiday," she added.
After the programme, Ball posted on Twitter: "Thank you splendid bunch of #BarkingLarkers for your fine company on Saturday mornings. I will miss y'all!"
Barking Larkers was the name Ball gave to her Radio 2 listeners.
Lynn Parsons will cover the Saturday breakfast show for the next few weeks, before a permanent replacement is announced.
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