The media mogul posted three combative messages today on his Twitter account, hitting back at the critics of News Corporation and its subsidiaries.
"Seems every competitor and enemy piling on with lies and libels. So bad, easy to hit back hard, which preparing," he tweeted first.
The outburst followed evidence presented in the BBC's Panorama this week alleging that News Corp subsidiary NDS was involved in a hacking and piracy campaign aimed at undermining ITV Digital, a key UK pay-TV rival to Murdoch's Sky in the early 2000s.
NDS has today written to the BBC complaining that the programme had "manipulated and mischaracterised" evidence, and called for an urgent retraction.
News Corp chief operating officer Chase Carey also accused the BBC of "gross misrepresentation" over the Panorama documentary, aired on Monday.
In a second tweet today, Murdoch outlined the different types of "enemies" that News Corp is facing.
"Enemies [have] many different agendas, but worst [are the] old toffs and rightwingers who still want last century's status quo with their monopolies," he posted.
His final tweet added: "Let's have it on! Choice, freedom of thought and markets, individual personal responsibility."
Alongside the BBC Panorama report, the alleged malpractices of NDS - which was recently sold to Cisco in a $5bn deal - were also covered in an investigation published by the Australian Financial Review, accusing the firm of similar pay-TV piracy in Australia.
Also this week, US public service channel PBS aired a 50-minute programme titled Murdoch's Scandal in the US and UK detailing the various controversies that have plagued the media mogul's empire.
But Carey claimed that the Australian Financial Review report and PBS Frontline documentary had "piled on - if not exaggerated - the BBC's inaccurate claims".