The Daily Mail writer, known for her infamous article about the downsides of being pretty, said that EL James's mega-selling book was damaging the status of females as "the moral compass of society".
"Giving it this name of mummy porn, using this kind of safe, middle-class word, makes women think it's okay to read it," she said during an appearance on This Morning.
"I'm not saying they shouldn't read it - but let's not kid ourselves. It's degrading. The character is a victim. She's a virgin. She's negotiating to become the main protagonist's sex slave.
"That's not where we are in the 21st century. Women are the moral compass of society. It's us people turn to in the banking crisis, in the recession."
She continued: "The nature of the content of the book is demeaning and degrading to who we are... For me there's a massive danger sign with this."
Brick also told hosts Phillip Schofield and Holly Willoughby that she believed Fifty Shades of Grey could cause physical harm to readers who replicate the BDSM and fetishism it contains.
"Without meaning to be flippant, sex games do go wrong," she explained. "Hospitals are full of people who have been injured this way.
"Deaths have occurred. S&M isn't to be taken lightly."
Fifty Shades of Grey, which began life as a piece of Twilight fan fiction, recently became the fastest adult paperback to reach one million sales.
A potential film version has also provoked widespread debate about who could play the book's lovers, with actors such as Ryan Gosling, Ian Somerhalder and Kristen Stewart frequently touted.