The Crown Prosecution Service (CPS) today (July 24) announced that ex-News of the World editor Brooks is among eight people who will be charged after being handed their files by the Metropolitan Police's Operation Weeting probe.
Andy Coulson, another former News of the World editor who went on to become David Cameron's director of communications, is also on the list, along with former staff at the paper Stuart Kuttner, Ian Edmondson, James Weatherup, Neville Thurlbeck, and Greg Miskiw.
Glenn Mulcaire, the private investigator jailed for phone hacking in 2007, is also to be charged with hacking offences.
The individuals are facing 19 charges in total, potentially relating to up to 600 high-profile individuals who authorities believe may have been the victims of phone hacking.
Kuttner, Brooks and Coulson are facing additional charges specifically in relation to the alleged hacking of the phone of Milly Dowler after the schoolgirl went missing in 2002.
She said that it is "particularly upsetting" to hear the charges over Dowler's voicemails.
"I did not authorise, nor was I aware of, phone hacking under my editorship," said Brooks.
"I am distressed and angry that the CPS have reached this decision when they knew all the facts and were in a position to stop the case at this stage.
"The charge concerning Milly Dowler is particularly upsetting, not only as it is untrue, but also because I have spent my journalistic career campaigning for victims of crime.
"I will vigorously defend these allegations."
Brooks is also facing trial over separate charges relating to her allegedly conspiring to pervert the course of justice in the phone hacking investigation.
Her husband, racehorse trainer Charlie Brooks, is also facing one charge for the same offence, along with four of her former colleagues.