Her comments, made last night (August 23) as part of the keynote speech at the Edinburgh TV Festival, are in stark contrast to those of her brother James on the same stage in 2009.
James Murdoch, the News Corporation executive who became embroiled in the phone hacking scandal, said that the BBC's size and ambition were "chilling", and also extolled the virtues of profit-led organisations such as Sky.
But Ms Murdoch, who sold her Shine Group production company to her father's News Corp last year, used the MacTaggart lecture to express support for the "universal licence fee". She also praised the BBC for its creative leadership.
However, she added that the "biggest challenge" facing the new BBC director general George Entwistle will "be to demonstrate how efficiently that funding is being spent on actual content".
Her speech appeared to show divisions in the Murdoch family, as she made a number of thinly-veiled criticisms of corporations that lack integrity and values.
Noting that writing the lecture had been "a welcome distraction from some of the other nightmares much closer to home", Ms Murdoch said that exposure of "sometimes self-serving relationships" between the pillars of society, such as the police, politics and the media, served as a reminder that "with great power comes responsibility".
In reference to the Leveson Inquiry launched last year into media ethics after the phone hacking scandal at her father's UK newspapers, she said that there should be "fierce protection of a free press and light touch media regulation".
However, she also noted that it was hard to argue for this because of the "unsettling dearth of integrity across so many of our institutions".
"Sadly, the greatest threats to our free society are too often from the enemies within," she said.
Some media commentators have viewed the lecture as Ms Murdoch's attempt to distance herself from the scandals at her father's company, which have dogged her brother James, prompting him to resign as chair of Sky and News International.
Speaking to BBC Radio 4's Media Show, Vanity Fair contributing editor Sarah Ellison said there was "no question" that Ms Murdoch harboured ambition within the News Corp empire.
"By distancing herself, the bet is that she'll be able to come back at a time when some of the scandal has passed her by and have a cleaner slate," she said.
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