The broadcaster has made the decision after witnessing record audiences of 3.5m tuning in for coverage of yesterday evening's medal triumphs (September 1).
As a result, sporting events that were due to be shown on sister channel More4 in the late afternoon will now be moved to Channel 4 for the duration of the Games.
Channel 4 will broadcast daily Paralympics coverage spanning almost 16 hours, beginning at 7am and ending at 11.15pm, with just a half-hour break for the Channel 4 News at 7pm.
The station also announced that Hollyoaks - which was expected to air on Channel 4 - will instead be broadcast on E4 at its usual time of 6.30pm between September 3 and September 10. E4's first look screening will follow as normal at 7pm.
"The coverage of the Paralympics has completely captured the public's imagination," said Channel 4's chief creative officer Jay Hunt.
"We are clearing our schedule to bring viewers even more of this fantastic sport."
Channel 4 plans to provide around 500 hours of coverage during the London 2012 Paralympic Games, split across its flagship channel and three Paralympics Extra live streams.