Brooks, the ex-boss of newspaper publisher News International, and Coulson, the former communications director to David Cameron, are expected at the Old Bailey along with five other former News of the World journalists.
They are all accused of one general charge of alleged conspiracy to access voicemails, which prosecutors have warned could relate to more than 600 victims.
Brooks also faces two other specific charges related to murdered schoolgirl Milly Dowler and former trade union boss Andy Gilchrist.
She previously said that she was "distressed and angry" by the charges, and insisted that she is "not guilty".
In July, the Crown Prosecution Service (CPS) announced that Brooks and Coulson were among eight people being charged by the Metropolitan Police's Operation Weeting probe into alleged hacking.
Other employees of the now defunct News of the World that were charged include ex-managing editor Stuart Kuttner, former news editor Greg Miskiw, former head of news Ian Edmondson, ex-reporter James Weatherup and former chief reporter Neville Thurlbeck.
Private investigator Glenn Mulcaire, who was jailed for hacking on behalf of the newspapers in 2007, faces four counts relating to specific people.
They will also all appear at the Old Bailey today.
In a separate case, Brooks is facing charges that she allegedly attempted to conceal evidence from police investigating phone hacking claims.
Her husband Charlie is also accused of the same offence, along with Brooks's chauffeur Paul Edwards, former personal assistant Cheryl Carter, head of security at News International Mark Hanna, and security employees Daryl Jorsling and Lee Sandell.