From today, the free TV companion experience is available to American users on iPhone and iPod Touch, along with Android devices and online.
The brainchild of Rose and ex-EMI executive Ernesto Schmidt, Zeebox went live last year in the UK as a 'digital couch', enabling users to interact and comment on TV shows via a second screen, such as a phone or tablet.
Viewers can browse TV listings and get personalised recommendations, as well as access additional content presented in real-time around what they are watching.
Alongside the social aspects, the Zeebox service also has commercial aspects, such as enabling consumers to discover and 'click-to-buy' products that they have seen on TV.
UK pay-TV giant Sky owns a 10% stake in the business and has an exclusive relationship in Britain to bundle the service into Sky mobile apps.
But in what is being described as an "unprecedented alliance", major US media firms Comcast Cable, NBCUniversal, HBO & Cinemax are all teaming with Zeebox in "a first-of-its-kind endorsement of a universal, cross-channel TV viewing companion app".
Comcast and NBCUniversal have invested in the US version of the app, and will promote the service to their customers and "enhance" hundreds of their TV shows to Zeebox, such as talent series The Voice and Notre Dame Football.
HBO and its sister network Cinemax will use Zeebox to create more engagement around their shows, such as Boardwalk Empire, True Blood and Strike Back.
Further US partners are to be announced in due course, said Zeebox.
NBCUniversal chief executive Steve Burke said: "We're excited to team with Zeebox on their US launch. As the Olympics demonstrated, the second screen experience has become an increasingly important platform to engage audiences.
"We think the Zeebox technology presents tremendous opportunities for our viewers and our advertisers."
Comcast Cable chief executive Neil Smit added: "Zeebox is a really compelling second-screen companion viewing platform, and we're excited to join such a strong group of industry partners in its launch.
"Zeebox will offer a unique nationwide TV companion experience that will make viewing live TV more engaging, compelling and fun."
Securing such a roster of high profile US partners is a real coup for Zeebox and will be a massive boost in its bid to break into the American market
Research released today by its investor Sky indicated that 75% of people now watch television accompanied by another screen, suggesting a potentially huge market for the Zeebox platform.
"We are proud to launch with this game-changing roster of partners who recognise the importance of fully meeting web-empowered consumer expectations," said Ernesto Schmitt, the chief executive and co-founder of Zeebox.
"As consumers continue to flock to social media and the web to experience a programme beyond what is on the screen, Zeebox gives content owners and programmers a direct line of communication, feedback and engagement that has never before been possible."
The US Zeebox will offer a full seven-day TV programme guide across all the major US television channels, including functionality to set show reminders.
Facebook and Twitter feeds are integrated for interaction with friends and celebrities while watching TV, or for discovering new content.
There are e-commerce links to relevant digital and physical products related to shows and the content of shows, while direct links to related video on-demand content from the broadcasters will be added in the near future
Zeebox also said that its new iPhone app in the US is optimised to the larger four-inch screen in the iPhone 5.
> Sky+ Guide launches catch-up TV section, iPad app integrates Zeebox functionality