The Adam and Joe Show was one of the most popular programmes on the station, attracting over 160,000 listeners a week and winning four Sony awards during the four years it was on the air.
Buxton's on-air partner Joe Cornish has subsequently embarked on a career as a film director: after releasing his debut Attack the Block last year. He is currently working on an adaptation of sci-fi novel Snow Crash. As a result, he has been unable to commit to a return to the airwaves.
However, BUG star Buxton will return to the Saturday 10am-1pm slot alongside Radio 1 presenter Bowman from November 17, appearing every Saturday morning in the run-up to Christmas, reports Radio Times.
Buxton said of the new show: "I've missed being on the radio so I'm delighted 6 Music have let me back into the Big British Castle for a few weeks, albeit without Joe who is busy slaving in a dream factory somewhere.
"To stop me from shrivelling up with loneliness Edith Bowman is going to join me which I'm very excited about as she's intelligent, professional, Scottish and a woman; qualities I value highly and in which Joe was almost entirely lacking. I just hope she doesn't mind occasional shouting and stupidity."
Bowman added: "I'm a big fan of 6 Music and what it stands for so I am really excited to be joining the team and to be working with Adam. It's going to be incredible fun although I know I will have my work cut out trying to keep up with Adam's dance moves."