Former BBC Formula One presenter Jake Humphrey is to front the live coverage on BT Sport, a new channel that will launch next year and show Premier League football and other sports.
Humphrey was based at the Olympic Park site this summer during the BBC's coverage of the London 2012 Games.
During the Olympics, the press centre and International Broadcast Centre at the Queen Elizabeth Olympic Park hosted 28,000 media covering the Games. After that, iCITY took over the building and it has now agreed a ten-year lease with BT to become the anchor tenant.
The site will become the home of the BT Sport channels, and BT will refit it to house three TV studios, a control centre, 20 edit suites and an audience holding area.
The Olympic park studios will be the production hub for all sports content that BT will offer, although some features and programming will come from the BT Tower.
BT Sport will show 38 live Premier League games each season for three years from August 2013. It also has rights to Aviva Premiership rugby union and club football from around the world.
BT chief executive Ian Livingstone said that the company was "leading the way to secure the Olympic sporting legacy for the community".
"We see this as a natural continuation of our role as official communications services partner for London 2012," he said.
Photo gallery - London 2012 Olympics best bits:
Copyright: PA Images"BT Sport will be a visible and engaged partner for the community and the studio will be a reminder of the incredible sporting feats we witnessed during the Olympics and Paralympics.
"The Olympic Park will be an iconic sporting backdrop for BT Sport. We want to create jobs in the area and to explore sporting links with local schools as well as looking at how we can offer our production facilities to other companies."
Mayor of London Boris Johnson said that iCITY and BT's "exciting proposal" will "transform part of the broadcast centre into the home of a major new TV channel creating hundreds of new jobs".
He added: "It offers the prospect of delivering our ambition and vision of a great employment legacy for Londoners from the Games and creating a new high tech and creative hub for London in Queen Elizabeth Olympic Park."
BT said that it will start work at the Olympic Park site on February 1, 2013, ahead of a launch of BT Sport in the summer of that year.