The Sherlock actor has been recognised in the 'Best Actor' category for this year's event.
The awards are in their second year, and aim to "pay tribute to the cultural importance of audio drama, on air and online". It will be held at BBC Broadcasting House on January 27.
Scott is nominated for his work in BBC Radio 4's production of Harold Pinter's play Betrayal, which is also nominated for 'Best Play'.
He will face competition from Henry Goodman in Radio 4's Ulysses and Richard Johnson for Tennyson and Edison on Radio 3.
Betrayal is nominated alongside On It by Tony Pitts and Robert M Pirsig's Zen and the Art of Motorcycle Maintenance by Peter Flannery - both for Radio 4.
Lorraine Ashbourne is nominated for 'Best Actress' for Radio 3's Seven Scenes, along with Michelle Fairley in The Grapes of Wrath on Radio 4, and Fenella Woolgar in An American Rose on Radio 4.
The 'Best Supporting Actor' category is between David Troughton for Singles and Doublets on Radio 3, and David Crellin for Craven and Carl Prekopp for Pilgrim, both on Radio 4.
Niamh Cusack is up for 'Best Supporting Actress' for The Man with Wings by Rachel Joyce, while there are also nods for Gillian Kearney for Songs and Lamentations and Vicky McClure in Kicking the Air, which are all Radio 4 productions.
David Tennant and Andrew Scott were among the winners at last year's inaugural event.