The broadcaster has confirmed that it will show over 45 hours from the Winter Games in Sochi, Russia, and 500 hours from the summer version in Rio de Janeiro, Brazil.
Channel 4 will also cover other major international para-sport events in the lead-up to Rio 2016, including July's IPC Athletics World Championships from Lyon, France, and August's IPC Swimming World Championships in Montreal, Canada.
The broadcaster has confirmed as well that the Games coverage will include episodes of The Last Leg, the late-night talk show that originally ran daily as part of the 2012 Paralympics, and which has already returned for a further series this year.
Channel 4's coverage of the London Paralympics attracted record viewing figures and was praised by the International Paralympic Committee (IPC) as going beyond its "wildest dreams".
International Paralympic Committee president Sir Philip Craven said of the new deal: "We are delighted to extend our partnership with Channel 4 following its stunning success in covering the London 2012 Paralympic Games.
Photo gallery - London 2012 Paralympics Team GB gold medal winners:
Copyright: PA Images David Davies/PA Wire"With London 2012, Channel 4 created a blueprint for how a commercial broadcaster can raise the profile of Paralympic sport and its athletes to new levels.
"They reached record audiences, in particular young people, identified and developed some fantastic new presenting talent and played a significant role in delivering seismic shifts in attitudes and perceptions towards people with an impairment in the UK.
"This is the first time the IPC has agreed a two-Games deal with a TV station and I would like to thank Sochi 2014 and Rio 2016 for their support and co-operation. To sign up such a high quality broadcaster so soon after the conclusion of the Games underlines the growth of the Paralympic Movement and the significant impact London 2012 had."
Channel 4 chief executive David Abraham said: "The London 2012 Paralympic Games was a landmark moment in the history of broadcasting Paralympic sport. Not only did Channel 4's coverage reach record audiences but, more importantly, it had a meaningful and positive impact on UK attitudes to disability and disability sport in general.
"I'm delighted that we have the opportunity to build on this achievement over the next four years and to work alongside the IPC to deliver both the Winter Games from Sochi in 2014 and the Summer Games from Rio in 2016."