The event, which runs from May 20-25, will bring the best of UK and US talent together on YouTube.
A live streamed variety show from Los Angeles kicks off the event on May 20, which will feature stars performing a mix of stand-up, sketches and musical performances.
The week's events will also include new episodes from some of YouTube's most popular comedy channels.
Rich Waterworth, head of YouTube marketing for Europe, said: "The UK is world renowned for its comedy and we're excited to announce that our homegrown talent will be joining the lineup for YouTube's first Comedy Week.
"YouTube is the home of comedy for the next generation so join us as we celebrate the best of comedy on YouTube."
Justin Gayner, founder of YouTube network ChannelFlip, is executive producer of the UK's Comedy Week.
Gayner said: "With 1 billion monthly viewers, YouTube is the largest platform on the planet. And that makes the inaugural YouTube Comedy Week the biggest single comedy event in history.
"We've got a stellar lineup of talent including famous favourites and some great new stars. There are going to be some amazing surprises during the week, so it's well worth a daily visit to see what treats we've got lined up.
"Creating comedy on YouTube over the last five years has been a hugely rewarding experience. Now that we have a direct relationship with our viewers and no restrictions on what we can make, the possibilities are endless."