Last week, the broadcaster agreed a deal with Big Brother producer Endemol to bring the programme back to TV screens, after it finished on Channel 4 last year.
Under the deal, a new "all-star celebrity" version of Big Brother will run for four weeks this summer, followed by a new series featuring members of the public in the autumn.
Channel 5, owned by billionaire Richard Desmond, will this week meet with media agencies to present a range of commercial opportunities to advertisers, including telephony sponsorship, hospitality, product placement and cross-media activity.
The Channel 5 commercial team, led by commercial sales director Nick Bampton, issued a one-page release to agencies last week, titled Big Brother Renaissance.
There will also be various opportunities for tie-ups with Desmond's Northern & Shell publications, including OK! magazine, the Daily Express and the Daily Star.
The popularity of Big Brother was starting to fade on Channel 4 in the show's final few years, but media buyers believe that it could be a winning format for Channel 5.
Chris Allen, head of vision at media agency MPG, told The Guardian: "It is a bold acquisition for Desmond, he has put his money where his mouth is.
"He is very tenacious and there is a great opportunity assuming he delivers on bringing in the right type of housemates, which he seems set to do."
Allen expressed his belief that Big Brother could earn Channel 5 more than £25m in its first year, particularly because the programme reaches a key younger audience.
He added: "The show will allow advertisers to engage with a hard-to-reach audience, a younger audience, and retail clients could well find the scheduling of the series in the run-up to Christmas a very attractive proposition. Of course it's not as big as it was, but neither is Coronation Street."