In an interview with AOL Television, the actress admitted that it would be difficult to persuade Hughes, who has not directed a film since 1991's Curly Sue, to helm a follow-up.
"It was something that I definitely wanted to do but John Hughes wasn't interested, and I didn't feel comfortable doing it without his involvement," she said.
"If we can get John to agree, I think it would be great. I think there are definitely a lot of people who would love to see it, and I would love to do it."
Sixteen Candles focused on awkward high-schooler Sam Baker (Ringwald) as she struggled to get through her sixteenth birthday.
Ringwald, 40, added: "I think that Sixteen Candles lends itself to [another film]. It was such a Cinderella story. And I was interested to see what happened to this girl."