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The actor revealed that he was disappointed by his jailed character's diminishing role in the books.
He reconsidered after Potter author JK Rowling promised that Malfoy would play a big part in the final novel, Harry Potter and the Deathly Hallows.
"There was a point where I wasn't sure I was going to do any more because there wasn't much for me to do in number five and I wasn't in number six," Isaacs told Comingsoon.net.
"I met Jo Rowling for the first time at a big awards dinner. I went over and basically fell to my knees and said, 'Get me out of prison, I beg you'. She looked over her shoulder and looked back at me mouthing, 'You're out. Chapter One'.
"And that was it, that's all I had to know, and I signed up immediately."
The sixth movie, Harry Potter and the Half-Blood Prince, will be released in November.
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