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The movie, which reunites Swingers stars Vince Vaughn and John Favreau, is based around four couples that visit a tropical island and end up taking part in relationship therapy.
Reno's character will be the therapist and resort operator, according to Variety.
Kristin Bell, Jason Bateman, Malin Akerman, Kristin Davis and Faizon Love are also attached to the project.
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