The actor, who spent five hours a day in make-up while shooting the 2007 movie, said he doesn't want to repeat himself.
"I think once is enough", he told The Sunday Herald Sun. "I did it and I did it well but I'm not a big sequel guy."
Hairspray, which is based on the stage musical adaptation of John Waters's 1988 film, focuses on an overweight teenager who grows up in 60s Baltimore dreaming of appearing on The Corny Collins Show.
> Click here to read our review of Hairspray