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Rex Features
The film about the Macedonian emperor, which also featured Angelina Jolie, Val Kilmer and Rosario Dawson, received a critical panning and poor box office takings on its release in 2004.
Farrell told Reuters that it took him a long time to recover from leading the Warner Bros. failure.
"Alexander hurt, you know - and again people are going to say 'Get over it, you were well paid' and all that. But Alexander hurt," he said.
"The response that it got was really painful and all of us got a really hard time, and I didn't come across too well either in the majority of reviews and even with the audiences - people did not respond to it.
"It was a film that was made to be seen by many people. Not many people saw it and they weren't particularly fond of it, and that was s****, it was really s****."
Farrell added that he took the criticism personally: "I felt like I had let a lot of people down, I felt like I had disappointed a lot of people... And it took a while to get over that."
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