The Farrellys, whose credits include Dumb And Dumber and There's Something About Mary, have been working on a modern Stooges incarnation since the '90s. They will direct from their own script, with a release scheduled for November 20, 2009.
Peter Farrelly said: "We love The Stooges! They have been sending the world into hysterics for more than 80 years.
"Movie-goers today deserve their own Stooges and we look forward to introducing them to a new generation of knuckleheads."
Beginning as a vaudeville act in 1925, The Three Stooges - Larry, Moe and Curly - have appeared in numerous TV specials, shorts and on home video.