Worthington is being lined up to play the role of Perseus in Louis Leterrier's Clash Of The Titans remake, while Cavill is to play King of Athens Theseus in Tarsem's War Of The Gods.
The Greek mythology movies are on course to arrive at a similar time since both will enter production within the next few months.
They are expected to cost less than $100 million each as they will be shot using greenscreen techniques similar to 300.
Australian actor Worthington will next be seen in sci-fi sequel Terminator Salvation. Cavill, who appears in The Tudors, is the male lead in Woody Allen's next movie Whatever Works.