Movies
The Monster star triumphed over fellow nominees Keisha Castle-Hughes (Whale Rider), Diane Keaton (Something's Gotta Give), Samantha Morton (In America) and Naomi Watts (21 Grams).
"This has been such an incredible year, I can't believe this," said Theron as she accepted her award. "I have to thank my incredible director Patty Jenkins, all of our producers, everybody at Media 8 and everybody at New Market.
"My incredible leading lady, Christina Ricci, you are truly the unsung hero of this film. I have to thank the entire crew, every single person who worked on this film. I couldn't have done it without you guys."
Once again Digital Spy readers were right on the money, with 36% of voters predicting Theron's success.
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