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The Valkyrie star, who was linked with the director's job earlier in the year, has reportedly now completed negotiations with Marvel.
"We're getting the story and visual effects together and all of that is very exciting," he said.
Thor tells the story of a disabled medical student whose alter ego is the Norse god of thunder Thor.
Earlier this month Daniel Craig denied rumours that he had been approached to play the title character. Other names linked to the role include Kevin McKidd and WWE wrestler Triple H.
Branagh's previous directing credits include Frankenstein, Hamlet and last year's Sleuth.
Thor is scheduled for release on June 10, 2010.
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