According to Variety, the project will mix CG characters with live-action footage to show how the bickering cat and mouse first became enemies. The story throws the pair together in Chigaco where they call a truce in order to find their way home.
Warners has been spurred on to make the film after seeing Fox's similar animated animal comedy Alvin And The Chipmunks gross $360 million at the box office.
Dan Lin will produce Tom And Jerry with Eric Gravning writing the script.
The characters were created by William Hanna and Joseph Barbera in 1940 and appeared in 114 shorts over the following 20 years. Legendary animator Chuck Jones produced further Tom And Jerry cartoons and a feature-length animated film was released in 1992.